منابع مشابه
Cellular pharmacology of amino acid derivatives of daunorubicin and doxorubicin in suspension of renal proximal tubules.
One approach currently being used to target drug action selectively to specific cells and tissues is to link active drugs to proteins and peptides that are preferentially recognized by, distributed to or activated by the target cells. Inasmuch as the kidney proximal tubule cells are very active in recapturing and catabolizing peptides and proteins which appear in the glomerular filtrate, we hav...
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The heme-enzyme soluble guanylyl cyclase (sGC) is an ubiquitous NO receptor, which mediates NO downstream signaling by the generation of cGMP. We studied the mechanism of action of the anthranilic acid derivatives 5-chloro-2-(5-chloro-thiophene-2-sulfonylamino-N-(4-(morpholine-4-sulfonyl)-phenyl)-benzamide sodium salt (HMR1766) (proposed international nonproprietary name, ataciguat sodium) and ...
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Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...
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In this issue of Hypertension is an article from several investigators in Stockholm, primarily of the Lundberg and Weitzberg groups at the Karolinska Institutet, which addresses one aspect of the potential use of orally ingested nitrite ions as therapies in humans for various diseases or, perhaps in food or food supplements, for some general improvement in cardiovascular or metabolic parameters...
متن کاملDerivatives of Glucuronic Acid
The presence of glucuronic acid in the complex molecules of specific bacterial polysaccharides (1) has stimulated a study of certain derivatives of this important substance and its lactone, glucuron. These investigations have entailed the necessity of elaborating a satisfactory method for preparing both the acid and its lactone, and at the same time they have embraced a study of the comparative...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1951
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1951.tb00674.x